DESI Drug List The Center for Medicaid and Medicare Services (CMS) Non-Reimbursable Drug Products The Drug Efficacy Study Implementation (DESI) was a program begun by the Food and Drug Administration (FDA) in the 1960s after the Kefauver-Harris Drug Control Act, which was passed in 1962, required all drugs be efficacious as well as safe. The link below is for a list of the drugs and associated National Drug Codes (NDC) that are coded as DESI and therefore are not reimbursable by the RI Medicaid program. DESI Drug List desi_list.pdf PDF file, less than 1mbmegabytes